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Learn How We Make Science and Technology Happen We support diverse research activities with talented staff, state-of-the-art facilities and core competencies. From internal collaboration to external partnerships, we work together to advance scientific discovery. The El Capitan supercomputer will give complex high-fidelity modeling, artificial intelligence and simulation an exascale boost. Learn how it will support national security and stockpile stewardship. Synthetic Biology - Postdoctoral Researcher Entry Level | Full-time Physical Life Sciences | Livermore, CA | 09/25/2024 Reference #: REF6526J Job Code: PDS.1 Post-Dr Research Staff 1 Organization: Physical and Life Sciences Position Type: Post Doctoral Security Clearance: None/Position does not require US citizenship (assignments longer than 179 days require a federal background investigation) Drug Test: Required for external applicant(s) selected for this position (includes testing for use of marijuana) Medical Exam: Not applicable Join us and make YOUR mark on the World! Are you interested in joining some of the brightest talent in the world to strengthen the United States’ security? Come join Lawrence Livermore National Laboratory (LLNL) where our employees apply their expertise to create solutions for BIG ideas that make our world a better place. We are committed to a diverse and equitable workforce with an inclusive culture that values and celebrates the diversity of our people, talents, ideas, experiences, and perspectives. This is essential to innovation and creativity for continued success of the Laboratory’s mission. Pay Range $108,840 Annually Job Description NOTE: This is a two-year Postdoctoral appointment with the possibility of extension to a maximum of three years. We are seeking a dedicated and hardworking postdoctoral researcher to conduct research in the field of synthetic biology for biocontainment of genetically modified microorganisms. You will actively participate in research to develop biocontainment circuits in environmentally relevant bacteria and build and screen libraries for protein redesign. This position is in the Microbial systems or Synthetic biology group in the Biosciences and Biotechnology Division. In this role you will Conduct fundamental research in microbial synthetic biology. Employ state of the art library generation and develop high throughput approaches to assay the functionality of protein variants and microbial fitness. Employ synthetic biology to implement biological circuits in environmental microorganisms and characterize efficacy in test beds of increasing complexity. Engineer microbial communities for robust function. Develop research plans, generate results, and publish peer-reviewed papers. Work with other scientists to write proposals and expand our program into new areas aligned with your expertise and interests. Write reports to funding agencies and participate in scientific conferences. Pursue independent (but complementary) research interests and interact with a broad spectrum of scientists internally and externally to the Laboratory. Publish research results in peer-reviewed scientific or technical journals and present results at external conferences, seminars, and/or technical meetings. Perform other duties as assigned. Qualifications PhD in Biological Sciences, Bioengineering, or a relevant field with a strong emphasis in synthetic biology and microbiology. Expertise and knowledge in bacterial genetics and physiology. Experience in engineering bacterial strains for environmental function. This might include design, assembly, and modeling of genetic circuits. Experience with high throughput screening/selection methods. Ability to develop independent research projects as demonstrated through publication of peer-reviewed literature. Proficient verbal and written communication and interpersonal skills to collaborate effectively in a multidisciplinary team environment and present and explain technical information. Experience with microbial evolution approaches (e.g., adaptive laboratory evolution). Experience with next-generation sequencing (NGS) execution and/or analysis. Experience with in silico protein design/engineering and/or directed experimental evolution of proteins. Experience with gene editing in non-model strains (non- E. coli systems). Experience with bacterial signaling systems (e.g., two component systems, quorum sensing systems). Experience with synthetic microbial communities for bioproduction or environmental application. Experience in bioinformatics and/or proficiency in programming in one or more of the following languages: Python, Julia, C, C++, R, Java, or Matlab. Additional Information All your information will be kept confidential according to EEO guidelines. Position Information This is a Postdoctoral appointment with the possibility of extension to a maximum of three years, open to those who have been awarded a PhD at time of hire date. Why Lawrence Livermore National Laboratory? Included in 2024 Best Places to Work by Glassdoor! Flexible schedules (*depending on project needs) None required. However, if your assignment is longer than 179 days cumulatively within a calendar year, you must go through the Personal Identity Verification process. This process includes completing an online background investigation form and receiving approval of the background check. (This process does not apply to foreign nationals.) Pre-Employment Drug Test External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor. Wireless and Medical Devices Per the Department of Energy (DOE), Lawrence Livermore National Laboratory must meet certain restrictions with the use and/or possession of mobile devices in Limited Areas. Depending on your job duties, you may be required to work in a Limited Area where you are not permitted to have a personal and/or laboratory mobile device in your possession. 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