Watertown, MA USA About Empress Empress is a privately-held early-stage biotech company advancing a proprietary platform to generate small molecule drugs faster and more predictably. Position Summary: We are seeking a motivated and enthusiastic Co-op to join our dynamic Synthetic Biology and Genomics Teams. This position offers an exciting opportunity to actively participate in cutting-edge workflows involving Next-Generation Sequencing (NGS) for transcriptomics and genomics, design and generate plasmid libraries using advanced synthetic biology techniques, and perform targeted transcriptional profiling using qRT-PCR and qPCR. Opportunities to gain hands-on experience in engineering mammalian cell lines with CRISPR-Cas9 technologies may also arise. The successful candidate will work in collaboration with the Biology, Immunology, and Computational Discovery teams to develop high-resolution molecular profiles that enhance drug discovery efforts. Key Responsibilities: Design, generate, and validate plasmid libraries using high-throughput cloning and state-of-the-art synthetic biology methodologies. Perform high-throughput nucleic acid extractions and prepare DNA and RNA libraries for NGS analysis. Utilize qPCR/qRT-PCR and other cell and molecular biology techniques to support research objectives. Conduct experiments efficiently under strict deadlines. Present research findings in team and cross-functional meetings. Maintain meticulous records in electronic lab notebooks. Basic Qualifications: Currently enrolled in a B.A./B.S. or M.S. degree program in Molecular Biology, Microbiology, Genetics, Biochemistry, or a related field. 0-2 years of experience in molecular biology, with a focus on nucleic acid manipulation, synthetic biology, and/or genomics. Preferred Qualifications: Familiarity with NGS sample preparation, including experience with Illumina and Oxford Nanopore platforms. Basic proficiency or strong interest in learning informatics tools such as R and/or Python. Keen interest in learning and applying lab automation instrumentation. Experience with mammalian cell culture techniques. A proactive, independent thinker with a keen eye for detail. Self-assured, collaborative team player with strong interpersonal skills. Exceptional written and verbal communication abilities. Flagship Pioneering Co-Op Program
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